| http://purl.uniprot.org/citations/14651970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14651970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14651970 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins containing the ARID (AT-rich interaction domain) DNA-binding motif regulate gene expression and differentiation in fungi, plants, and animals. This report describes phenotypes resulting from targeted disruption of the ARID gene Mrf-2. Homozygous loss of Mrf-2 resulted in a high rate of neonatal mortality that was partially strain-dependent: survival of Mrf-2(-/-) pups ranged from 6.4% on the 129S1 genetic background to 38% on a mixed 129S1.C57Bl/6J background. Loss of Mrf-2 expression did not affect embryonic survival, embryonic growth or birth weight. Lipid accumulation was severely reduced in brown adipose of Mrf-2(-/-) neonates at 24h of age, however, and Mrf-2(-/-) mice weighed significantly less than controls from postnatal day five onward. Adult Mrf-2(-/-) mice were lean, with significant reductions in brown and white adipose tissues, and in the percentage of body fat. Mrf-2(-/-) and Mrf-2(+/-) mice were also resistant to weight gains and obesity when maintained on high-fat diets. These phenotypes suggest that Mrf-2 is essential for accumulation of lipid stores in postnatal life."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.11.026"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.11.026"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Huang T.H."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Huang T.H."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Itakura K."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Itakura K."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Tsark W."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Tsark W."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Whitson R.H."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/author | "Whitson R.H."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/pages | "997-1004"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/pages | "997-1004"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/title | "Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/title | "Neonatal mortality and leanness in mice lacking the ARID transcription factor Mrf-2."xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/14651970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14651970 |
| http://purl.uniprot.org/citations/14651970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14651970 |