| http://purl.uniprot.org/citations/14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14652021 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in DJ-1 gene have been linked to autosomal recessive early onset parkinsonism (AR-EOP). Although the mechanism of neuronal cell death due to DJ-1 mutation has not been fully elucidated, loss of DJ-1 function was considered to cause the phenotype. Here, we demonstrated that the down regulation of endogenous DJ-1 of the neuronal cell line by siRNA enhanced the cell death which was induced by oxidative stress, ER stress, and proteasome inhibition, but not by pro-apoptotic stimulus. The cell death with hydrogen peroxide was dramatically rescued by over-expression of wild-type DJ-1, but not by that of L166P mutant DJ-1. Furthermore, DJ-1 rescued the cell death caused by over-expression of Pael receptor, which was a substrate of Parkin, another gene product for autosomal recessive juvenile parkinsonism. These results suggest that loss of protective activity of DJ-1 from neuro-toxicity induced by these stresses contributes to neuronal cell death in AR-EOP with mutant DJ-1."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.11.056"xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Sugawara K."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Takahashi R."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Yokota T."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Ariga H."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/author | "Mizusawa H."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/pages | "1342-1348"xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/title | "Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition."xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/14652021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14652021 |
| http://purl.uniprot.org/citations/14652021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14652021 |
| http://purl.uniprot.org/uniprot/Q99497#attribution-40140E065B88BA7263597C9DBD5E7E20 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/Q99LX0#attribution-4E5B0778A05B04A50310BFE1D20AC0BF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_D3K2X3-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_A2A813-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_A2A815-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_A2A816-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_A2A817-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_Q99497-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |
| http://purl.uniprot.org/uniprot/#_Q99LX0-mappedCitation-14652021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14652021 |