| http://purl.uniprot.org/citations/14654946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14654946 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to analyze differential gene expression of putative prostate tumor markers we compared the expression levels of >400 cancer-related genes using the cDNA array technique in a set of prostate tumors and matched normal prostate tissues. Up-regulated expression of mammary tumor 8 kDa protein (MAT-8), complement component C1S (C1S), ferritin heavy chain (FTH1), peptidyl-prolyl cis-trans isomerase A (PPIA), RNA-binding protein regulatory subunit DJ-1 protein (DJ-1) and vacuolar ATP synthase subunit F (ATP6V1F) was determined in prostate carcinoma and confirmed by using quantitative real-time RT-PCR analyses. Furthermore, quantitative real time RT-PCR on intact RNAs from 11 paired laser microdissected epithelial tissue samples confirmed up-regulated MAT-8 expression in 6 out of 11 prostate tumors. To determine the function of MAT-8 in vitro, human PC-3 and LNCaP prostate carcinoma cells were transfected with small interfering double-stranded RNA (siRNA) oligonucleotides against the MAT-8 gene leading to a specific down-regulation of MAT-8 expression. In addition, suppression of MAT-8 expression caused a significant decrease in cellular proliferation of both prostate cancer cell lines, whereas invasive capacity and cellular apoptosis remained unaffected. Taken together, our results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Voigt S."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Grzmil M."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Burfeind P."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Hemmerlein B."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Thelen P."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/author | "Helmke K."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/pages | "97-105"xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/title | "Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14654946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14654946 |
| http://purl.uniprot.org/citations/14654946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14654946 |
| http://purl.uniprot.org/uniprot/#_A0A1S5UZ23-mappedCitation-14654946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14654946 |
| http://purl.uniprot.org/uniprot/#_Q14802-mappedCitation-14654946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14654946 |
| http://purl.uniprot.org/uniprot/#_Q13254-mappedCitation-14654946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14654946 |
| http://purl.uniprot.org/uniprot/Q13254 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14654946 |
| http://purl.uniprot.org/uniprot/Q14802 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14654946 |
| http://purl.uniprot.org/uniprot/A0A1S5UZ23 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14654946 |