| http://purl.uniprot.org/citations/14657012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14657012 | http://www.w3.org/2000/01/rdf-schema#comment | "Pregnancy-associated plasma protein A (PAPP-A) cleaves IGF-binding protein-4 (IGFBP-4) and appears to enhance local IGF bioavailability in response to injury. In this study we determined the effects of growth factors and cytokines involved in the healing process on PAPP-A expression in human dermal fibroblasts. There was no effect of platelet-derived growth factor, epidermal growth factor, or basic fibroblast growth factor on PAPP-A mRNA expression in these cells. However, treatment with the proinflammatory cytokines, TNFalpha and IL-1 beta, resulted in time- and dose-dependent increases in PAPP-A mRNA and protein expression (3-to 4-fold maximal effects), which were prevented by actinomycin D. On the other hand, interferon-gamma (IFN gamma) treatment markedly inhibited PAPP-A expression. IGFBP-4 proteolytic activity was increased 4-fold in medium from TNFalpha- and IL-1 beta-treated (1 nm) cells and decreased 40% in medium from IFN gamma-treated (1 nm) cells. IGF-I-stimulated [(3)H]thymidine incorporation was significantly enhanced by pretreatment with 1 nm TNFalpha, and this enhancement was blocked in the presence of protease-resistant IGFBP-4. In conclusion, PAPP-A expression is regulated by inflammatory cytokines in adult human fibroblasts, with functional consequences on IGFBP-4 protease activity and IGF-I bioavailability. These data provide a mechanism for the regulation of PAPP-A in response to injury and further implicate PAPP-A in the wound-healing processes."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2003-1313"xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Oxvig C."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Chen B.K."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Overgaard M.T."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Resch Z.T."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Conover C.A."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/author | "Bale L.K."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/pages | "1124-1129"xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/title | "Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/14657012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14657012 |
| http://purl.uniprot.org/citations/14657012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14657012 |
| http://purl.uniprot.org/uniprot/#_B4DTA7-mappedCitation-14657012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14657012 |
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