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http://purl.uniprot.org/citations/14657022http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14657022http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14657022http://www.w3.org/2000/01/rdf-schema#comment"ARC92/ACID1 was identified as a novel specific target of the herpes simplex transactivator VP16 using an affinity purification procedure. Characterization of the protein revealed tight interactions with human Mediator mediated through a von Willebrand type A domain. ARC92/ACID1 further contains a novel activator-interacting domain (ACID), which it shares with at least one other human gene termed PTOV1/ACID2. The structure of ARC92/ACID1 is of ancient origin but is conserved in mammals and in selected higher eukaryotes. A subpopulation of Mediator is associated with ARC92/ACID1, which is specifically required for VP16 activation both in vitro and in mammalian cells, but is dispensable for other activators such as SP1. Despite many known targets of VP16, ARC92/ACID1 appears to impose a critical control on transcription activation by VP16 in mammalian cells."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.org/dc/terms/identifier"doi:10.1093/emboj/cdg619"xsd:string
http://purl.uniprot.org/citations/14657022http://purl.org/dc/terms/identifier"doi:10.1093/emboj/cdg619"xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Lottspeich F."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Lottspeich F."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Kremmer E."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Kremmer E."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Mittler G."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Mittler G."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Meisterernst M."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Meisterernst M."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Uhlmann T."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Uhlmann T."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Berti L."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Berti L."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Santolin L."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Santolin L."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Stuehler T."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/author"Stuehler T."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/name"EMBO J."xsd:string
http://purl.uniprot.org/citations/14657022http://purl.uniprot.org/core/name"EMBO J."xsd:string