http://purl.uniprot.org/citations/14657200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/14657200 | http://www.w3.org/2000/01/rdf-schema#comment | "This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as tissues of transgenic animals and genetically altered steroidogenic and nonsteroidogenic cells overexpressing the SR-B proteins. Using both biochemical and morphological techniques, we have seen that these dimeric and higher order oligomeric forms of SR-BI expression are strongly associated with both functional and morphological expression of the selective HDL cholesteryl ester uptake pathway. Rats and mice show some species differences in expression of SR-BII dimeric forms; this difference does not extend to the use of SR-B cDNA types for transfection purposes. In a separate study, cotransfection of HEK293 cells with cMyc and V5 epitope-tagged SR-BI permitted coprecipitation and quantitative coimmunocytochemical measurements at the electron microscope level, suggesting that much of the newly expressed SR-BI protein in stimulated cells dimerizes and that the SR-BI dimers are localized to the cell surface and specifically to microvillar or double membraned intracellular channels. These combined data suggest that SR-BI self-association represents an integral step in the selective cholesteryl ester uptake process."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300370-jlr200"xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/author | "Nomoto A."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/author | "Azhar S."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/author | "Leers-Sucheta S."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/author | "Reaven E."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/author | "Cortez Y."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/pages | "513-528"xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/title | "Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues."xsd:string |
http://purl.uniprot.org/citations/14657200 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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