| http://purl.uniprot.org/citations/14662849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14662849 | http://www.w3.org/2000/01/rdf-schema#comment | "Transgenic (Tg) L2 mice expressing high levels of the lambda2 (315) L chain contain only B cell populations involved in the first line of defense, i.e., B-1 and marginal zone (MZ) B cells. The strongly oligoclonal IgH chain repertoire of Tg B-1a cells in such mice was attributed to strong positive selection by autoantigens. In this study, we show that the MZ B cells of L2 mice correspond very closely to MZ B cells of normal mice, as revealed by surface marker expression and gene expression profiling. We demonstrate that the IgH chain repertoire of these Tg MZ B cells is extremely heterogeneous. This is in sharp contrast to the oligoclonality found in B-1a cells of the same mice, which was attributed to strong positive selection mediated by autoantigens. Therefore, the strong positive selection of the IgH chain repertoire in L2 mice is B-1a specific. Thus, our data demonstrate that despite common functional properties, MZ B and B-1a cells exhibit striking differences in their selection and/or maintenance requirements."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.171.12.6495"xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Weiss S."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Hoffmann R."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Kretschmer K."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Jungebloud A."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Kleinke T."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/author | "Stopkowicz J."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/pages | "6495-6501"xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/title | "The selection of marginal zone B cells differs from that of B-1a cells."xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://purl.uniprot.org/core/volume | "171"xsd:string |
| http://purl.uniprot.org/citations/14662849 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14662849 |
| http://purl.uniprot.org/citations/14662849 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14662849 |
| http://purl.uniprot.org/uniprot/P25918#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/P13379#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/P19070#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/P20693#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/P01872#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/A0A0A6YW14#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/A0A0A6YXD7#attribution-4FEEE7BDE70C33FF3D199422C2950384 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW14-mappedCitation-14662849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14662849 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWG3-mappedCitation-14662849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14662849 |