| http://purl.uniprot.org/citations/14664814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14664814 | http://www.w3.org/2000/01/rdf-schema#comment | "Ephrin-As are repulsive axonal guidance cues that regulate retinotectal projection. EphA tyrosine kinases, which are the receptors of ephrin-As, activate signaling cascades leading to cytosckeleton reorganization. Here, we address the role of cyclin-dependent kinase (Cdk) 5 in Eph receptor signaling induced by ephrin-A5. Ephrin-A5 induced a cell morphological response in PC-3M cells that endogenously express Cdk5 and EphA2, a receptor for ephrin-A5. This response was augmented by the transfection of p35, which is a neuronal regulator of Cdk5. While the morphological response of native PC-3M cells was not affected by olomoucine, an inhibitor of Cdk, the response was inhibited in the p35-transfected cells. In retinal ganglion cells, either olomoucine at 20 microM or Y-27632 at 10 microM, an inhibitor of Rho-kinase/ROKalpha/ROCKII, showed maximum inhibitory effect against ephrin-A5 (10 microg/ml)-induced growth cone collapse. Combined application of olomoucine and Y-27632 further suppressed the ephrin-A5-induced response. Ephrin-A5 evoked phosphorylation of Cdk5 at Tyr15 and tau, a substrate of Cdk5 in retinal growth cones. Recombinant herpes simplex virus expressing Cdk5 mutant (kinase-negative or Tyr15 to Ala) showed a dominant-negative effect on the ephrin-A5-induced growth cone collapse. These findings demonstrate that both Cdk5 and the Rho kinase pathway independently contribute to the downstream of ephrin-A-induced signaling in retinal ganglion cells."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1044-7431(03)00220-3"xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Goshima Y."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Nakayama T."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Sugiyama Y."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Cheng Q."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Nakamura F."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Shoji M."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/author | "Mizuki N."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/pages | "632-645"xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/title | "Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells."xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14664814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14664814 |
| http://purl.uniprot.org/citations/14664814 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14664814 |
| http://purl.uniprot.org/uniprot/#_Q00535-mappedCitation-14664814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14664814 |
| http://purl.uniprot.org/uniprot/Q00535 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14664814 |