| http://purl.uniprot.org/citations/14668345 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14668345 | http://www.w3.org/2000/01/rdf-schema#comment | "Lecithin-cholesterol acyltransferase deficiency is frequently associated with hypertriglyceridemia (HTG) in animal models and humans. We investigated the mechanism of HTG in the ldlr-/- x lcat-/-(double knockout (dko)) mice using the ldlr-/-x lcat+/+ (knock-out (ko)) littermates as control. Mean fasting triglyceride (TG) levels in the dko mice were elevated 1.75-fold compared with their controls (p < 0.002). Both the very low density lipoprotein and the low density lipoprotein/intermediate density lipoprotein fractions separated by fast protein liquid chromatography were TG-enriched in the dko mice. In vitro lipolysis assay revealed that the dko mouse very low density lipoprotein (d < 1.019 g/ml) fraction separated by ultracentrifugation was a more efficient substrate for lipolysis by exogenous bovine lipoprotein lipase. Post-heparin lipoprotein lipase activity was reduced by 61% in the dko mice. Hepatic TG production rate, determined after intravenous Triton WR1339 injection, was increased 8-fold in the dko mice. Hepatic mRNA levels of sterol regulatory element binding protein-1 (srebp-1) and its target genes acetyl-CoA carboxylase-1 (acc-1), fatty acid synthase (fas), and stearoyl-CoA desaturase-1 (scd-1) were significantly elevated in the dko mice compared with the ko control. The hepatic mRNA levels of LXRalpha (lxralpha) and its target genes including angiopoietin-like protein 3 (angptl-3) in the dko mice were unchanged. Fasting glucose and insulin levels were reduced by 31 and 42%, respectively in the dko mice, in conjunction with a 49% reduction in hepatic pepck-1 mRNA (p = 0.014). Both the HTG and the improved fasting glucose phenotype seen in the dko mice are at least in part attributable to an up-regulation of the hepatic srebp-1c gene."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m309439200"xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Xie C."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Connelly P.W."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Lam E."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Ng D.S."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Maguire G.F."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/author | "Ugwu F."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/pages | "7636-7642"xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/title | "Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance."xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14668345 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14668345 |
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