| http://purl.uniprot.org/citations/14668487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14668487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14668487 | http://www.w3.org/2000/01/rdf-schema#comment | "Dynamic rearrangements of cell-cell adhesion underlie a diverse range of physiological processes, but their precise molecular mechanisms are still obscure. Thus, identification of novel players that are involved in cell-cell adhesion would be important. We isolated a human kelch-related protein, Kelch-like ECT2 interacting protein (KLEIP), which contains the broad-complex, tramtrack, bric-a-brac (BTB)/poxvirus, zinc finger (POZ) motif and six-tandem kelch repeats. KLEIP interacted with F-actin and was concentrated at cell-cell contact sites of Madin-Darby canine kidney cells, where it colocalized with F-actin. Interestingly, this localization took place transiently during the induction of cell-cell contact and was not seen at mature junctions. KLEIP recruitment and actin assembly were induced around E-cadherin-coated beads placed on cell surfaces. The actin depolymerizing agent cytochalasin B inhibited this KLEIP recruitment around E-cadherin-coated beads. Moreover, constitutively active Rac1 enhanced the recruitment of KLEIP as well as F-actin to the adhesion sites. These observations strongly suggest that KLEIP is localized on actin filaments at the contact sites. We also found that N-terminal half of KLEIP, which lacks the actin-binding site and contains the sufficient sequence for the localization at the cell-cell contact sites, inhibited constitutively active Rac1-induced actin assembly at the contact sites. We propose that KLEIP is involved in Rac1-induced actin organization during cell-cell contact in Madin-Darby canine kidney cells."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-07-0531"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-07-0531"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Ishida H."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Ishida H."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Hara T."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Hara T."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Kamijo K."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Kamijo K."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Raziuddin R."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Raziuddin R."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Dorkhom S."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/author | "Dorkhom S."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/pages | "1172-1184"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/pages | "1172-1184"xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/title | "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells."xsd:string |
| http://purl.uniprot.org/citations/14668487 | http://purl.uniprot.org/core/title | "Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells."xsd:string |