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http://purl.uniprot.org/citations/14669229http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14669229http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association of the NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a northern Chinese population.

Methods

The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) analysis in 193 patients with ESCC and 141 unrelated healthy controls.

Results

The frequency of the T allele (null) among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.86, P=0.028). The NQO1 C/C and C/T genotype distribution among ESCC patients was not significantly different from that among healthy controls (Chi-square= 2.27 and 0.127; P=0.132 and 0.721, respectively). However, the T/T genotype frequency among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.39, P=0.036). The NQO1 T/T genotype significantly increased the risk for developing ESCC, compared to the combination of C/C and C/T genotypes, with the adjusted odds ratio (OR) of 1.81 (95%CI: 1.04-3.15). This increased susceptibility exhibited pronouncedly in patients with family history of upper gastrointestinal cancers (adjusted OR=2.22, 95%CI 1.18-4.17).

Conclusion

Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate high-risk individuals for ESCC."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"He M."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Guo W."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Wang R."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Zhang L.W."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Zhang J.H."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Wang S.J."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Chen Z.F."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Wu M.L."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Kuang G."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Sarbia M."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Wei L.Z."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/author"Wen D.G."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/pages"544-546"xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/title"[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]."xsd:string
http://purl.uniprot.org/citations/14669229http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/14669229http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14669229
http://purl.uniprot.org/citations/14669229http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14669229
http://purl.uniprot.org/uniprot/#_B4DQP5-mappedCitation-14669229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14669229
http://purl.uniprot.org/uniprot/#_B4DLR8-mappedCitation-14669229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14669229
http://purl.uniprot.org/uniprot/#_H3BNV2-mappedCitation-14669229http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14669229
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