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| http://purl.uniprot.org/citations/14670949 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytochrome P450 2E1 (CYP2E1) is highly inducible in a subset of astrocytes in vivo following ischemic or mechanical injury and in vitro by lipopolysaccharide (LPS) or interleukin-1beta. We have studied the mechanism of induction, and found that transcriptional activation of CYP2E1 occurred within 3 h, and CYP2E1 dependent catalytic activity was induced more than 4-fold within 5 h. The induction was sensitive to several tyrosine kinase inhibitors, and was further modulated by inhibitors of p38 MAP kinase. MAP kinase kinase-3 (MKK3) was phosphorylated in response to LPS, and expression of constitutively active MKK3, but not the MAP kinase kinases MEKK1 or MKK1, activated CYP2E1. Transcriptional activation was mediated through a C/EBPbeta and -delta binding element situated at -486/-474, and appeared to involve activation of prebound factors as well as recruitment of newly synthesized C/EBPbeta and -delta. It is thus suggested that LPS induces MKK3 activation in astrocytes, which in turn stimulates a C/EBPbeta and -delta binding element to mediate transcriptional activation of CYP2E1."xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311850200"xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/author | "Tindberg N."xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/author | "Kelicen P."xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/pages | "15734-15742"xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/title | "Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPbeta and -delta."xsd:string |
| http://purl.uniprot.org/citations/14670949 | http://purl.uniprot.org/core/volume | "279"xsd:string |
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