| http://purl.uniprot.org/citations/14672706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14672706 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14672706 | http://www.w3.org/2000/01/rdf-schema#comment | "An autofeedback loop associated with transcription of clock gene(s), Per(s), is generally accepted as the molecular machinery of circadian rhythm generation, in which CLOCK/BMAL act as positive regulators and PER/CRY as negative ones. We show here an autofeedback loop of Dec1 encoding a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression. Three CACGTG E-boxes are responsible for both the activation and the suppression of Dec1 transcription. Forced expression of Clock/Bmal increased endogenous Dec1 mRNA level, and overexpression of Dec1 resulted in suppression of Dec2, Per2, and Dbp expression. The level of Dec1 expression in the heart of Clock/Clock mutant mice was continuously low throughout the day. These findings suggest that Dec1 is positively regulated by CLOCK/BMAL and is involved in circadian rhythm regulation by suppressing CLOCK/BMAL-induced gene expression. The autofeedback loop of Dec1 may be interlocked with the core feedback loop of Per in some situations."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.11.099"xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.11.099"xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Kawamoto T."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Kawamoto T."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Sato F."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Sato F."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Takeda N."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Furukawa M."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Furukawa M."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Nagai R."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Nagai R."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Maemura K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Maemura K."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Noshiro M."xsd:string |
| http://purl.uniprot.org/citations/14672706 | http://purl.uniprot.org/core/author | "Noshiro M."xsd:string |