| http://purl.uniprot.org/citations/14676194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14676194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14676194 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesothelin is a glycosylphosphatidylinositol-linked cell surface molecule expressed in the mesothelial lining of the body cavities and in many tumor cells. Based on the finding that a soluble form of mesothelin specifically binds to ovarian carcinoma cell line OVCAR-3, we isolated cDNAs encoding a mesothelin-binding protein by expression cloning. The polypeptides encoded by the two cloned cDNA fragments matched to portions of CA125, an ovarian cancer antigen and a giant mucin-like glycoprotein present at the surface of tumor cells. By flow cytometric analysis and immunoprecipitation, we demonstrate that CA125 binds to mesothelin in a specific manner. Binding of CA125 to membrane-bound mesothelin mediates heterotypic cell adhesion as anti-mesothelin antibody blocks binding of OVCAR-3 cells expressing CA125 to an endothelial-like cell line expressing mesothelin. Finally, we show that CA125 and mesothelin are co-expressed in advanced grade ovarian adenocarcinoma. Taken together, our data indicate that mesothelin is a novel CA125-binding protein and that CA125 might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to mesothelin."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m312372200"xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m312372200"xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Takeuchi M."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Rump A."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Rump A."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Morikawa Y."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Morikawa Y."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Miyajima A."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Miyajima A."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Minami S."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Minami S."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Umesaki N."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/author | "Umesaki N."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/pages | "9190-9198"xsd:string |
| http://purl.uniprot.org/citations/14676194 | http://purl.uniprot.org/core/pages | "9190-9198"xsd:string |