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| http://purl.uniprot.org/citations/14679168 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic lipase clears plasma cholesterol by lipolytic and nonlipolytic processing of lipoproteins. We hypothesized that the nonlipolytic processing (known as the bridging function) clears cholesterol by removing apoB-48- and apoB-100-containing lipoproteins by whole particle uptake. To test our hypotheses, we expressed catalytically inactive human HL (ciHL) in LDL receptor deficient "apoB-48-only" and "apoB-100-only" mice. Expression of ciHL in "apoB-48-only" mice reduced cholesterol by reducing LDL-C (by 54%, 46 +/- 6 vs. 19 +/-8 mg/dl, P < 0.001). ApoB-48 was similarly reduced (by 60%). The similar reductions in LDL-C and apoB-48 indicate cholesterol removal by whole particle uptake. Expression of ciHL in "apoB-100-only" mice reduced cholesterol by reducing IDL-C (by 37%, 61 +/- 19 vs. 38 +/-12 mg/dl, P < 0.003). Apo-B100 was also reduced (by 27%). The contribution of nutritional influences was examined with a high-fat diet challenge in the "apoB-100-only" background. On the high fat diet, ciHL reduced IDL-C (by 30%, 355 +/-72 vs. 257 +/-64 mg/dl, P < 0.04) but did not reduce apoB-100. The reduction in IDL-C in excess of apoB-100 suggests removal either by selective cholesteryl ester uptake, or by selective removal of larger, cholesteryl ester-enriched particles. Our results demonstrate that the bridging function removes apoB-48- and apoB-100-containing lipoproteins by whole particle uptake and other mechanisms."xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300459-jlr200"xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/author | "Qian K."xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/author | "Dichek H.L."xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/author | "Agrawal N."xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/pages | "551-560"xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/title | "The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient "apoB-48-only" and "apoB-100-only" mice."xsd:string |
| http://purl.uniprot.org/citations/14679168 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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