| http://purl.uniprot.org/citations/14681050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14681050 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of astrocytic gap junctions in ischemia remains controversial. Several studies support that astrocytic gap junctions play a role in the spread of hypoxic injury, while other reports have demonstrated that blocking astrocytic gap junctions increases neuronal death. Using a stroke model on animals in which the astrocytic gap junction protein connexin43 (Cx43) was compromised, we explored the neuroprotective role of astrocytic gap junctions. A focal brain stroke was performed on heterozygous Cx43 null [Cx43(+/-)] mice, wild type [Cx43(+/+)] mice, astrocyte-directed Cx43 deficient [Cx43(fl/ fl)/hGFAP-cre] mice (here designated as Cre(+) mice), and their corresponding controls [Cx43(fl/fl)] (here designated as Cre(-) mice). Four days following stroke, ischemic lesions were measured for size and analyzed immunohistochemically. Stroke volume was significantly larger in Cx43(+/-) and Cre(+) mice compared to Cx43(+/+) and Cre(-) mice, respectively. Apoptosis as detected by TUNEL labeling and caspase-3 immunostaining was amplified in Cx43(+/-) and Cre(+) mice compared to their control groups. Furthermore, increased inflammation as characterized by the immunohistochemical staining of the microglial marker CD11b was observed in the Cre(+) mice penumbra. Astrocytic gap junctions may reduce apoptosis and inflammation in the penumbra following ischemic insult, suggesting that coupled astrocytes fulfill a neuroprotective role under ischemic stroke conditions."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.org/dc/terms/identifier | "doi:10.1080/cac.10.4-6.413.417"xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Theis M."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Naus C.C."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Willecke K."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Nakase T."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Fushiki S."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/author | "Sohl G."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/name | "Cell Commun Adhes"xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/pages | "413-417"xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/title | "Neuroprotective role of astrocytic gap junctions in ischemic stroke."xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/14681050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14681050 |
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