| http://purl.uniprot.org/citations/14684870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14684870 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14684870 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal stressors such as hypoxia and firing of action potentials at very high frequencies cause intracellular Na+ to rise and ATP to be consumed faster than it can be regenerated. We report the cloning of a gene encoding a K+ channel, Slick, and demonstrate that functionally it is a hybrid between two classes of K+ channels, Na+-activated (KNa) and ATP-sensitive (KATP) K+ channels. The Slick channel is activated by intracellular Na+ and Cl- and is inhibited by intracellular ATP. Slick is widely expressed in the CNS and is detected in heart. We identify a consensus ATP binding site near the C terminus of the channel that is required for ATP and its nonhydrolyzable analogs to reduce open probability. The convergence of Na+, Cl-, and ATP sensitivity in one channel may endow Slick with the ability to integrate multiple indicators of the metabolic state of a cell and to adjust electrical activity appropriately."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-37-11681.2003"xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.23-37-11681.2003"xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Joiner W.J."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Joiner W.J."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Bhattacharjee A."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Bhattacharjee A."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Kaczmarek L.K."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Kaczmarek L.K."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Sigworth F.J."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/author | "Sigworth F.J."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/pages | "11681-11691"xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/pages | "11681-11691"xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/title | "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP."xsd:string |
| http://purl.uniprot.org/citations/14684870 | http://purl.uniprot.org/core/title | "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP."xsd:string |