| http://purl.uniprot.org/citations/14685157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14685157 | http://www.w3.org/2000/01/rdf-schema#comment | "ATP-binding cassette (ABC) transporters are involved in the transport of multiple substrates across cellular membranes, including metabolites, proteins, and drugs. Employing a functional fluorochrome export assay, we found that UVB irradiation strongly inhibits the activity of ABC transporters. Specific inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) restored the function of ABC transporters in UVB-irradiated cells, and PARP-1-deficient cells did not undergo UVB-induced membrane transport inhibition. These data suggest that PARP-1 activation is necessary for ABC transporter functional downregulation. The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Furthermore, ADP-ribose molecules potently inhibited the activity of the ABC transporter P-glycoprotein. Hence, poly(ADP-ribose) metabolism appears to play a novel role in the regulation of ABC transporters."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401348"xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Herrmann M."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Voll R.E."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Gaipl U.S."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Heyder P."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Kalden J.R."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Dumitriu I.E."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/author | "Kolowos W."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/pages | "314-320"xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/title | "UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase."xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/14685157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14685157 |
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