| http://purl.uniprot.org/citations/14688346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688346 | http://www.w3.org/2000/01/rdf-schema#comment | "Elucidation of the factors involved in host defense against human immunodeficiency viral infection remains pivotal if viral control may be achieved. Toward these ends, we investigated the function of a putative antiretroviral factor, OTK18, isolated by differential display of mRNA from HIV type 1-infected primary human monocyte-derived macrophages. Molecular and immunohistochemical analyses showed that the OTK18 nucleotide sequence contains 13 adjacent C(2)H(2)-type zinc finger motifs, a Krüppel-associated box, and is localized to both cytosol and nucleus. Mutational analyses revealed that both the Krüppel-associated box and zinc finger regions of OTK18 are responsible for the transcriptional suppressive activities of this gene. OTK18 was copiously expressed in macrophages following HIV type I infection and diminished progeny virion production. A mechanism for this antiretroviral activity was by suppression of HIV type 1 Tat-induced viral long terminal repeat promoter activity. Our findings suggest that one possible function of OTK18 is as a HIV type 1-inducible transcriptional suppressor."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.1.381"xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.1.381"xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Carlson K.A."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Carlson K.A."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Gendelman H.E."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Gendelman H.E."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Leisman G."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Leisman G."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Horiba M."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Horiba M."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Ikezu T."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Ikezu T."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Buescher J."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Buescher J."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Limoges J."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Limoges J."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Pohlman G.D."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/author | "Pohlman G.D."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/14688346 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |