| http://purl.uniprot.org/citations/14688378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688378 | http://www.w3.org/2000/01/rdf-schema#comment | "This report describes the difference in the epitope generation of two isoforms of self-tumor Ag CML66 and the regulation mechanism. We identified a new CML66 short isoform, termed CML66-S. The previously identified long CML66 is referred to as CML66-L. CML66-S shares the C terminus with CML66-L but has its unique N terminus. CML66-S is predominantly expressed in testis, but is also expressed in very low levels in tumor cells, whereas CML66-L is expressed in tumor cells and testis. Differential expression of CML66-L and CML66-S in tumor cells resulted from regulation at transcription, although alternative splicing also participated in the generation of the isoforms. In addition, Ab titers to a CML66-L peptide were significantly higher than that to CML66-S peptide in the sera from patients with tumors. Finally, the Abs to full-length CML66-L in the sera from patients with tumors were correlated with the Abs in the sera from these patients to CML66-L-38, which is a fusion protein with a CML66-L-specific N terminus. This suggests that the CML66-L isoform is mainly responsible for the epitope generation. Our studies have identified the alternative promoter in combination with alternative splicing as a novel mechanism for regulation of the epitope generation of a self-tumor Ag."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.1.651"xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.1.651"xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Phan L."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Phan L."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Xiong Z."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Xiong Z."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Wu C.J."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Wu C.J."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Ng B."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Ng B."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang X.-F."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Yang X.-F."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Talpaz M."xsd:string |
| http://purl.uniprot.org/citations/14688378 | http://purl.uniprot.org/core/author | "Talpaz M."xsd:string |