| http://purl.uniprot.org/citations/14688481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688481 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688481 | http://www.w3.org/2000/01/rdf-schema#comment | "The DF3/MUC1 mucin-like transmembrane oncoprotein is overexpressed by most human carcinomas. The MUC1 cytoplasmic domain (CD) binds directly to the Wnt effector, beta-catenin, and colocalizes with beta-catenin in the nucleus; however, the nuclear function of MUC1 is unknown. The present results demonstrate that MUC1 coactivates transcription of beta-catenin-Tcf-binding sites in the pTOPFLASH reporter. Activation of transcription was abrogated by expression of MUC1 with a Y-46->F mutation in the CD that attenuates binding of MUC1 and beta-catenin. We also show that transcription of the Wnt responsive cyclin D1 promoter is activated by MUC1, but not MUC1(Y46F), and that the cyclin D1 gene is upregulated in MUC1-positive cells. In concert with these results, MUC1-induced anchorage-independent growth and tumorigenicity were also abrogated by mutating MUC1 at the Y-46 site. These findings support a model in which the MUC1 functions as a transforming protein by coactivating transcription of Wnt target genes."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Ren J."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/author | "Kharbanda S."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/name | "Cancer Biol. Ther."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/name | "Cancer Biol. Ther."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/pages | "702-706"xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/pages | "702-706"xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/title | "MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/title | "MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation."xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/14688481 | http://purl.uniprot.org/core/volume | "2"xsd:string |