| http://purl.uniprot.org/citations/14688793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14688793 | http://www.w3.org/2000/01/rdf-schema#comment | "nt signalling pathways regulate cell proliferation, cell fate and morphogenetic movements. Here, we demonstrate that the Frizzled (Fz) family of Wnt receptors, similarly to G-protein-coupled receptors (GPCRs), form specific homo- and hetero-oligomers. Two lines of evidence suggest that oligomerization occurs in the endoplasmic reticulum: first, a mutant allele of Fz4, encoding a truncated protein that is retained in the endoplasmic reticulum, is linked to the autosomal-dominant retinal degenerative disease, familial exudative vitreoretinopathy (FEVR). We show that this mutant form of Fz4 oligomerizes with wild-type Fz4, retains it in the endoplasmic reticulum and inhibits its signalling. Second, a derivative of Fz1 targeted to the endoplasmic reticulum traps wild-type Fz1 in the endoplasmic reticulum and blocks its signalling. These data support the hypothesis that oligomerization of mutant and wild-type Fz proteins occurs in the endoplasmic reticulum and may explain the genetic dominance of this FEVR allele."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1081"xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Bouvier M."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Kaykas A."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Shah K.V."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Yang-Snyder J."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/author | "Heroux M."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/pages | "52-58"xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/title | "Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization."xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/14688793 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14688793 |
| http://purl.uniprot.org/citations/14688793 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14688793 |
| http://purl.uniprot.org/uniprot/Q08463#attribution-5917569FE1662D18669B660502B49D1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q08463#attribution-88BB6C866D5827E7BA0FA72DA76FB764 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q08463#attribution-97B4EB58C42D41C1E125A94551E29AF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q9ULV1#attribution-88BB6C866D5827E7BA0FA72DA76FB764 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q9ULV1#attribution-97B4EB58C42D41C1E125A94551E29AF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q08464#attribution-5917569FE1662D18669B660502B49D1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q08464#attribution-88BB6C866D5827E7BA0FA72DA76FB764 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
| http://purl.uniprot.org/uniprot/Q08464#attribution-97B4EB58C42D41C1E125A94551E29AF2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14688793 |
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