| http://purl.uniprot.org/citations/1469024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1469024 | http://www.w3.org/2000/01/rdf-schema#comment | "The natural killer cell activity of splenocytes from rats with scald injury was observed to be significantly suppressed at 7 days after injury compared with that of normal nonburned controls. Incubation of splenocytes from normal rats or rats with burn injury with either rat interleukin-2 or rat interferon (IFN-alpha and IFN-beta) significantly increased the natural killer cell activity. Addition of a rabbit anti-rat interferon antibody to spleen cells incubated with interleukin-2 did not produce any significant alteration in interleukin-2-related enhancement of natural killer cell activity. These results suggest that enhancement of natural killer cell activity after incubation of splenocytes with interleukin-2 is not due to interferon production but is an independent event. Preincubation of spleen cells with a mouse monoclonal antibody to rat interleukin-2 receptor was observed to abolish the interleukin-2-related enhancement of natural killer cell activity completely, whereas it partially blocked the interferon-related enhancement. These results were also confirmed by enhancement of natural killer cell activity of burned rats after in vivo administration of interleukin-2. Our studies thus indicate that after thermal injury, the observed decrease of natural killer cell activity can be enhanced by both interleukin-2 and interferon independently of each other. The decreased natural killer cell activity may be due to a decrease in interleukin-2 production or availability and not to an interleukin-2 receptor defect. These studies thus point toward a potential therapeutic significance of interleukin-2 in enhancing immune function after thermal injury."xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.org/dc/terms/identifier | "doi:10.1097/00004630-199211000-00002"xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/author | "Abdullah A."xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/author | "Herndon D.N."xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/name | "J Burn Care Rehabil"xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/pages | "617-622"xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/title | "Effects of rat interleukin-2 and rat interferon on the natural killer cell activity of rat spleen cells after thermal injury."xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/1469024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1469024 |
| http://purl.uniprot.org/citations/1469024 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1469024 |
| http://purl.uniprot.org/uniprot/P26896#attribution-065B300E5C1C942AA0D65686A1082E20 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1469024 |
| http://purl.uniprot.org/uniprot/#_A0A0G2KA53-mappedCitation-1469024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1469024 |
| http://purl.uniprot.org/uniprot/#_P26896-mappedCitation-1469024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1469024 |
| http://purl.uniprot.org/uniprot/A0A0G2KA53 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1469024 |
| http://purl.uniprot.org/uniprot/P26896 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1469024 |