| http://purl.uniprot.org/citations/14693705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14693705 | http://www.w3.org/2000/01/rdf-schema#comment | "Proinflammatory cytokines are believed to be important in pancreatic beta-cell destruction in the development of type 1 diabetes. They act by upregulation of genes including Fas and inducible nitric oxide synthase (iNOS), which have both been shown to lead to beta-cell death in vitro. We used mice deficient in the interleukin (IL)-1 receptor (IL-1R) to assess the contribution of IL-1 to different models of diabetes. IL-1R-deficient islets were protected from the damaging effects of tumor necrosis factor (TNF) and interferon (IFN)-gamma in vitro, and beta-cell expression of iNOS was reduced, suggesting that IL-1 mediates the induction of iNOS by TNF and IFN-gamma. IL-1 action was not required for induction of class I major histocompatibility complex or Fas by TNF and IFN-gamma. IL-1R-deficient nonobese diabetic (NOD) mice developed diabetes significantly slower than wild-type mice. IL-1R deficiency did not affect diabetes in 8.3 TCR transgenic NOD mice but prolonged the time to diabetes in BDC2.5 TCR transgenic NOD mice. We conclude that IL-1R deficiency slows progression to diabetes in NOD mice but on its own does not prevent diabetes."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.53.1.113"xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Thomas H.E."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Brodnicki T.C."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Santamaria P."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Irawaty W."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Allison J."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Darwiche R."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/author | "Kay T.W."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/pages | "113-121"xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/title | "IL-1 receptor deficiency slows progression to diabetes in the NOD mouse."xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/14693705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14693705 |
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