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http://purl.uniprot.org/citations/14694653http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14694653http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the polymorphism of delta-aminolevulinic acid dehydratase(ALAD) and the genetic susceptibility to lead toxicity in Uighur and Yi population in China.

Methods

The ALAD genotypes were determined by PCR and MspI restriction fragment length polymorphism techniques in 214 Uighur individuals from Xinjiang autonomous region and 144 Yi individuals from Yunnan province. The correlation between the polymorphism of ALAD and blood lead levels, and the factors affecting the latter were explored.

Results

The frequencies of the allele ALAD1 and ALAD2 in Uighur are 0.91 and 0.09; and in Yi are 0.98 and 0.02 respectively. In Uighur the average blood lead level was (76 +/-4) microgram/L, and 25.7% individuals with blood lead level > or = 100 micrograms/L. In Yi the average blood lead level was (50 +/-16) microgram/L, and 6.3% individuals with blood lead level > or = 100 micrograms/L. However, no statistic correlation between the distribution of ALAD alleles and the blood lead level was found in both populations.

Conclusion

The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"He X."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Lu J."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Lu X."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Xie G."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Wu R."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/author"Cui T."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/name"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/pages"277-281"xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/title"[The polymorphism of delta-aminolevulinic acid dehydratase and genetic susceptibility to lead toxicity in Uighur and Yi population in China]."xsd:string
http://purl.uniprot.org/citations/14694653http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/14694653http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14694653
http://purl.uniprot.org/citations/14694653http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14694653
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http://purl.uniprot.org/uniprot/P13716http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/14694653
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