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http://purl.uniprot.org/citations/14697523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14697523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14697523http://www.w3.org/2000/01/rdf-schema#comment"The prolactin-inducible protein (PIP/GCDFP15) family consists of small secretory polypeptides that are found in various body fluids. In order to study evolutionary events to this family, we cloned member genes and analyzed their sequences. A database search revealed the presence of a novel paralogous gene on mouse chromosome 6q34 and a nonprocessed pseudogene adjacent to PIP on human chromosome 7q34. The mouse PIP and four related genes displayed higher nonsynonymous and synonymous substitution ratios in comparison to other mammalian PIP orthologues; furthermore, these genes exhibited distinct distributions among tissues such as seminal vesicle, colon, and mammary gland. A pair of duplicated genes could have existed prior to radiation to the human and rodents. While only PIP is active in the human lineage, species-specific gene duplications have given rise to functional variants in rodents. Adaptive evolution potentially has occurred among the PIP and its related genes in the mouse genome."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.org/dc/terms/identifier"doi:10.1016/j.gene.2003.10.013"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.org/dc/terms/identifier"doi:10.1016/j.gene.2003.10.013"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Horiuchi H."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Horiuchi H."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Kaneko M."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Kaneko M."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Tian W."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Tian W."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Osawa M."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/author"Osawa M."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/name"Gene"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/pages"179-186"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/pages"179-186"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/title"Divergent evolution of the prolactin-inducible protein gene and related genes in the mouse genome."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/title"Divergent evolution of the prolactin-inducible protein gene and related genes in the mouse genome."xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/volume"325"xsd:string
http://purl.uniprot.org/citations/14697523http://purl.uniprot.org/core/volume"325"xsd:string
http://purl.uniprot.org/citations/14697523http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14697523
http://purl.uniprot.org/citations/14697523http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14697523