| http://purl.uniprot.org/citations/14699070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14699070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14699070 | http://www.w3.org/2000/01/rdf-schema#comment | "In the fission yeast Schizosaccharomyces pombe, three genes that function in the RNA interference (RNAi) pathway, ago1+, dcr1+, and rdp1+, have recently been shown to be important for timely formation of heterochromatin and accurate chromosome segregation. In the present study, we present evidence that null mutants for ago1+ and dcr1+ but not rdp1+, exhibit abnormal cytokinesis, cell cycle arrest deficiencies, and mating defects. Subsequent analyses showed that ago1+ and dcr1+ are required for regulated hyperphosphorylation of Cdc2 when encountering genotoxic insults. Because rdp1+ is dispensable for this process, the functions of ago1+ and dcr1+ in this pathway are presumably independent of their roles in RNAi-mediated heterochromatin formation and chromosome segregation. This was further supported by the finding that ago1+ is a multicopy suppressor of the S-M checkpoint deficiency and cytokinesis defects associated with loss of Dcr1 function, but not for the chromosome segregation defects of this mutant. Accordingly, we conclude that Dcr1-dependent production of small interfering RNAs is not required for enactment and/or maintenance of certain cell cycle checkpoints and that Ago1 and Dcr1 functionally diverge from Rdp1 to control cell cycle events in fission yeast. Finally, exogenous expression of hGERp95/EIF2C2/hAgo2, a human Ago1 homolog implicated in posttranscriptional gene silencing, compensated for the loss of ago1+ function in S. pombe. This suggests that PPD proteins may also be important for regulation of cell cycle events in higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-06-0433"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-06-0433"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Ekwall K."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Ekwall K."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Hobman T.C."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Hobman T.C."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Carmichael J.B."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Carmichael J.B."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Provost P."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/author | "Provost P."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/pages | "1425-1435"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/pages | "1425-1435"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/title | "ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/title | "ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/14699070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14699070 |
| http://purl.uniprot.org/citations/14699070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14699070 |