| http://purl.uniprot.org/citations/14699124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14699124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14699124 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have identified the DUB family of cytokine-regulated murine deubiquitinating enzymes, which play a role in the control of cell proliferation and survival. Through data base analyses and cloning, we have identified a human cDNA (DUB-3) that shows significant homology to the known murine DUB family members. Northern blotting has shown expression of this gene in a number of tissues including brain, liver, and muscle, with two transcripts being apparent (1.6 and 1.7 kb). In addition, expression was observed in cell lines including those derived from a number of hematopoietic tumors such as the Burkitt's lymphoma cell line RAJI. We have also demonstrated that DUB-3, which was shown to be an active deubiquitinating enzyme, is induced in response to interleukin-4 and interleukin-6 stimulation. Finally, we have demonstrated that constitutive expression of DUB-3 blocks proliferation and can initiate apoptosis in both IL-3-dependent Ba/F3 cells and NIH3T3 fibroblasts. These findings suggest that human DUB-3, like the murine DUB family members, is transiently induced in response to cytokines and can, when constitutively expressed, block growth factor-dependent proliferation."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311291200"xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311291200"xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Baek K.-H."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Baek K.-H."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Humbert M."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Humbert M."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Burrows J.F."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Burrows J.F."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "McGrattan M.J."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "McGrattan M.J."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Rascle A."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/author | "Rascle A."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/pages | "13993-14000"xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/pages | "13993-14000"xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/title | "DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation."xsd:string |
| http://purl.uniprot.org/citations/14699124 | http://purl.uniprot.org/core/title | "DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation."xsd:string |