| http://purl.uniprot.org/citations/14700595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14700595 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA) encoded susceptibility to develop type 1 diabetes mellitus (T1DM) has been investigated in children from North India. The results revealed significantly increased prevalence of HLA-A26, -B8, and -B50 among patients and strong positive association of the disease with DRB1*0301 (82.1% vs 13.9%, chi2=71.3, odds ratio [OR]=28.3) and a negative association with DRB1*02 (chi2=12.2, PF=38.5). HLA-DQB1*0201 occurred in 96.4% of the patients, whereas the heterodimer DQA1*0501-DQB1*0201 was present in 82.1% of patients (60.7% in single dose and 21.4% in double dose) and revealed significant deviation from the healthy controls (chi2=74.1, pc=6.0E-10). In addition to DRB1*03, positive association was also observed with DRB1*09 (14.3% vs 1.3%, chi2=13.4) and DRB1*04 (39.3% vs 15.6%, chi2=8.39). No HLA association was observed in relation to residual pancreatic beta-cell function or associated thyroid autoimmunity. Family analysis revealed involvement of multiple DR3+ve haplotypes with T1DM in North Indian children with A26-B8-DRB1*03 (25% vs 3.5%, chi2=16.9, p=3.96E-05) and Ax-B50-DRB1*03 (25% vs 0.7%, chi2=44.7, p=9.88E-11) being the most frequent haplotypes encountered among patients. The classical Caucasian haplotype A1-B8-DRB1*03 was infrequent (7.2%) among the diabetic children. The study highlights the race specificity of HLA association and disease associated HLA haplotypes in T1DM among North Indian children."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2003.10.013"xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/author | "Menon P.S."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/author | "Mehra N.K."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/author | "Kanga U."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/author | "Jaini R."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/author | "Vaidyanathan B."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/pages | "47-53"xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/title | "HLA haplotypes associated with type 1 diabetes mellitus in North Indian children."xsd:string |
| http://purl.uniprot.org/citations/14700595 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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