| http://purl.uniprot.org/citations/14701907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14701907 | http://www.w3.org/2000/01/rdf-schema#comment | "Basal and forced swimming (FS) stress-induced release of noradrenaline (NA) and serotonin (5-HT) were determined by in vivo microdialysis in the ventral hippocampus of mice overexpressing galanin under the platelet-derived growth factor B promoter (GalOE/P) or under the dopamine beta-hydroxylase promoter (GalOE/D) (only NA). WT mice served as controls. Intraventricular infusion of galanin significantly reduced basal extracellular NA in WT mice and in GalOE/P mice (albeit less so). Microdialysis sampling during a 10-min FS showed that NA and 5-HT release were elevated to 213% and 156%, respectively, in the GalOE/P group, whereas in the WT group the increases were only 127% and 119%, respectively. The second (repeated) 10-min FS (RFS) caused a marked enhancement of NA and 5-HT release in the GalOE/P mice to 344% and 275%, respectively. However, the RFS caused only a 192% increase of extracellular NA levels in the GalOE/D mice. Pretreatment with the putative peptidergic galanin receptor antagonist M35 almost completely blocked the elevation of NA and 5-HT levels in the GalOE/P after RFS. These results suggest that the NA and 5-HT hippocampal afferents in GalOE/P mice are hypersensitive to both conditioned and unconditioned stressful stimuli, such as FS, and that this effect is mediated by galanin receptors. The present findings support a role of galanin in the regulation of release of NA and 5-HT, two neurotransmitters involved in mood control."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0307042101"xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Yamaguchi M."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Crawley J.N."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Wang F.H."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Kehr J."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Steiner R."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Bartfai T."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Hokfelt T."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Ogren S.O."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Holmberg K."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Yoshitake T."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/author | "Kuteeva E."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/pages | "354-359"xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/title | "Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test."xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/14701907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14701907 |
| http://purl.uniprot.org/citations/14701907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14701907 |
| http://purl.uniprot.org/uniprot/#_A0A498WGR4-mappedCitation-14701907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14701907 |
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| http://purl.uniprot.org/uniprot/#_P47212-mappedCitation-14701907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14701907 |
| http://purl.uniprot.org/uniprot/P47212 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14701907 |