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| http://purl.uniprot.org/citations/14704854 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt proteins signal via cell surface receptors termed Frizzleds. Frizzleds display many properties characteristic of members of the superfamily of G-protein-coupled receptors, including heptihelical hydropathy plots; an exofacial N-terminal region that is glycosylated; a cytoplasmic C-terminal region that includes canonical motifs for phosphorylation by protein kinase A, protein kinase C and casein kinase II; cytoplasmic domains that couple to heterotrimeric G proteins, as evidenced by a GTP-shift in receptor affinity; receptor-mediated responses sensitive to depletion of specific G protein subunits and receptor-mediated responses sensitive to bacterial toxins that target G proteins. Evidence from a variety of developmental systems demonstrates Wnt-Frizzled (Fz) signaling via pathways other than the Wnt/beta-catenin pathway linked to transcription controlled by Lef/Tcf. Prominent among these additional pathways is a Wnt-Fz pathway regulating intracellular [Ca(++)] and cyclic GMP levels. The essential role of heterotrimeric G proteins in Wnt-Fz signaling is highlighted."xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-003-3165-x"xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/author | "Malbon C.C."xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/pages | "69-75"xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/title | "Wnt-frizzled signaling to G-protein-coupled effectors."xsd:string |
| http://purl.uniprot.org/citations/14704854 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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