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http://purl.uniprot.org/citations/14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14706339http://www.w3.org/2000/01/rdf-schema#comment"The Fos protein, a major component of the AP-1 transcription factor, is essential for osteoclast differentiation, acts as an oncogene, potentiates transforming signals, and controls invasive growth and angiogenesis during tumor progression. To investigate a potential genetic interaction between the Trp53 and Fos pathways, Trp53/Fos double knockout mice were generated. These mice develop highly proliferative and invasive rhabdomyosarcomas of the facial and orbital regions, with more than 90% penetrance at 6 months of age. Rhabdomyosarcoma cell lines established from the primary tumors express characteristic muscle-specific markers, and reexpression of Fos is associated with enhanced apoptosis in vitro. Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.org/dc/terms/identifier"doi:10.1016/s1535-6108(03)00280-0"xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/author"Wagner E.F."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/author"Jochum W."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/author"Eferl R."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/author"Fleischmann A."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/author"Witowsky J."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/name"Cancer Cell"xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/pages"477-482"xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/title"Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene."xsd:string
http://purl.uniprot.org/citations/14706339http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/14706339http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14706339
http://purl.uniprot.org/citations/14706339http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14706339
http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_O70366-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_Q80ZA1-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_P01101-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_Q64451-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339
http://purl.uniprot.org/uniprot/#_Q3U463-mappedCitation-14706339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14706339