| http://purl.uniprot.org/citations/14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14707141 | http://www.w3.org/2000/01/rdf-schema#comment | "hGTSE-1 (human G(2) and S phase-expressed-1) is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with the microtubules. hGTSE-1 is able to down-regulate levels and activity of the p53 tumor suppressor protein: it binds the C-terminal region of p53 and represses its ability to induce apoptosis after DNA damage. Here we report that, after DNA damage, hGTSE-1 becomes stabilized in a p53-independent way and accumulated in the nucleus. Further characterization of hGTSE-1 localization revealed increased nuclear staining in unstressed cells after treatment with the nuclear export inhibitor leptomycin B, or when a nuclear export signal (NES) located in its C-terminal region was mutated. Finally, we provide evidence that hGTSE-1 ectopic expression, in addition to p53 protein levels down-regulation, is able to enhance cytoplasmic localization of p53. Interestingly, NES-mutated hGTSE-1 accumulates in the nucleus, binds p53 but looses its ability to enhance cytoplasmic redistribution of p53 and to regulate p53 protein levels. Similarly, when wild type hGTSE-1 functions on p53 were analyzed in cells lacking Mdm2, it failed in regulating both p53 localization and protein levels, thus indicating that hGTSE-1 requires an intact NES and functional Mdm2 for the regulation of p53. Our results provide new insights into the mechanism of hGTSE-1 function, whereby its characterized nucleo-cytoplasmic shuttling ability is required to regulate p53."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m311123200"xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Marchionni L."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Schneider C."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Collavin L."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Del Sal G."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Benetti R."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/author | "Monte M."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/pages | "11744-11752"xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/title | "hGTSE-1 expression stimulates cytoplasmic localization of p53."xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14707141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14707141 |
| http://purl.uniprot.org/citations/14707141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14707141 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_B4DZT6-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_Q13200-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |
| http://purl.uniprot.org/uniprot/#_Q14997-mappedCitation-14707141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14707141 |