| http://purl.uniprot.org/citations/14710184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14710184 | http://www.w3.org/2000/01/rdf-schema#comment | "Chemotaxis is the result of a refined interplay among various intracellular molecules that process spatial and temporal information. Here we present a modular scheme of the complex interactions between the front and the back of cells that allows them to navigate. First, at the front of the cell, activated Rho-type GTPases induce actin polymerization and pseudopod formation. Second, phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is produced in a patch at the leading edge, where it binds pleckstrin-homology-domain-containing proteins, which enhance actin polymerization and translocation of the pseudopod. Third, in Dictyostelium amoebae, a cyclic-GMP-signalling cascade has been identified that regulates myosin filament formation in the posterior of the cell, thereby inhibiting the formation of lateral pseudopodia that could misdirect the cell."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.embor.7400051"xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/author | "Bosgraaf L."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/author | "Loovers H.M."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/author | "Postma M."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/author | "Van Haastert P.J."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/pages | "35-40"xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/title | "Chemotaxis: signalling modules join hands at front and tail."xsd:string |
| http://purl.uniprot.org/citations/14710184 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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