| http://purl.uniprot.org/citations/14711818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14711818 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the functions of the DNA/RNA-binding protein TB-RBP in somatic cells, we examined cultured primary mouse embryonic fibroblasts (MEFs) derived from TB-RBP-deficient mice. The TB-RBP-deficient MEFs exhibit a reduced growth rate compared with MEFs from littermates. Reintroduction of TB-RBP remedies this defect. A partner protein of TB-RBP, Translin-associated factor X (TRAX), was absent in TB-RBP-deficient MEFs, despite normal TRAX mRNA levels. TRAX is dependent upon the presence of TB-RBP and is removed from null MEFs following ubiquitination. Re-introduction of TB-RBP, but not TB-RBP lacking an oligomerization domain, into null MEFs stabilized TRAX protein without changing TRAX mRNA levels. The coordinated expression of TB-RBP and TRAX is also seen in synchronized cells, where the amount of TRAX protein but not TRAX RNA closely parallels TB-RBP levels throughout the cell cycle. In transgenic mice overexpressing TRAX in testis, total TB-RBP and TRAX levels are constant with reductions of endogenous TRAX compensating for exogenous TRAX. Using RNA interference, reductions of either TB-RBP or TRAX (without affecting TB-RBP) slow cell growth rates. We conclude that TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313133200"xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Cho Y.S."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Hecht N.B."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Underkoffler L.A."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Chennathukuzhi V.M."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/author | "Loomes K."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/pages | "12605-12614"xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/title | "Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14711818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14711818 |
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