| http://purl.uniprot.org/citations/14712229 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14712229 | http://www.w3.org/2000/01/rdf-schema#comment | "Ras proteins mediate the proliferative effects of G-protein-coupled receptors (GPCRs), but the role of Rap proteins in GPCR signaling is unclear. We have developed a novel cellular proliferation assay for examining signal transduction to Rap utilizing Ras-rap chimeras that respond selectively to Rap-specific exchange factors, but which stimulate cellular proliferation through Ras effectors. Both the D1 dopamine receptor (Gs-coupled) and the 5HT1E serotonin receptor (Gi-coupled) mediated cellular proliferation in a Ras/rap chimera-dependent manner. Responses to both receptors were PKA-independent. Both receptors activated Ras/rap and full-length Rap as measured by activation-specific probes. Pertussis toxin blocked Ras/rap-dependent responses to 5HT1E but not D1. Ras/rap-dependent responses to both receptors were insensitive to beta-gamma scavengers. Responses to 5HT1E, but not D1, were sensitive to inhibition by a dominant-negative C3G fragment, by the Src-like kinase inhibitors PP1 and PP2, and by a dominant-negative mutant of Src. Very similar data were obtained for two other Gi-coupled receptors, the D2 dopamine receptor and the alpha2C adrenergic receptor. A constitutively active mutant of Galphai2 also mediated Ras/rap-dependent responses. These data indicate that GPCRs coupled to pertussis-toxin-sensitive G-proteins activate Rap through a Galpha subunit, C3G, and Src-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207014"xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/author | "Essex A."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/author | "Burstein E.S."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/author | "Weissman J.T."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/author | "Ma J.N."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/pages | "241-249"xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/title | "G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway."xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/14712229 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14712229 |
| http://purl.uniprot.org/citations/14712229 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14712229 |
| http://purl.uniprot.org/uniprot/Q99MK8#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/Q01337#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P61168#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/Q01279#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P01132#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/Q61616#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P62874#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P08752#attribution-8F54C9A7477699470B04502ADD84107B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P63213#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |
| http://purl.uniprot.org/uniprot/P20612#attribution-D3AA311B1B666EE2AD6FCDC757FCBE9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14712229 |