| http://purl.uniprot.org/citations/14718356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14718356 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelial cells can convert l-citrulline to l-arginine, the precursor of nitric oxide. The present study tests the hypothesis that a C-to-A nucleotide transversion (T1405N) in the gene-encoding carbamoyl-phosphate synthetase 1, the enzyme catalyzing the rate-limiting step in l-citrulline formation, influences nitric oxide metabolite concentrations or nitric oxide-mediated vasodilation in humans. Bradykinin (100, 200, and 400 ng/min) was infused via brachial artery in 106 (CC:AC:AA=40:54:12) healthy subjects. Sodium nitroprusside (1.6, 3.2, and 6.4 microg/min) was also infused in 87 (CC:AC:AA=31:46:10) subjects. Forearm blood flow was measured by plethysmography and blood samples were collected for tissue-type plasminogen activator antigen, nitric oxide metabolites, and cyclic GMP. There was a significant relationship between carbamoyl-phosphate synthetase 1 genotype and nitric oxide metabolites, such that nitric oxide metabolite concentrations were highest in individuals homozygous for the C allele (mean+/-SD, 14.0+/-8.5 micromol/L), lowest in individuals homozygous for the A allele (9.1+/-3.1 micromol/L), and intermediate (11.8+/-6.6 micromol/L) in heterozygotes (P=0.036). There was a significant effect of carbamoyl-phosphate synthetase 1 genotype on forearm blood flow during bradykinin (P=0.028), such that the vasodilator response was greatest in C allele homozygotes (22.2+/-9.1 mL/min/100 mL at 400 ng/min), least in A allele homozygotes (13.6+/-6.2 mL/min/100 mL), and intermediate (19.4+/-10.7 mL/min/100 mL) in heterozygotes. Similarly, carbamoyl-phosphate synthetase 1 genotype influenced forearm blood flow during nitroprusside (maximal flow 19.2+/-8.3, 18.1+/-8.3, and 11.5+/-4.9 mL/min/100 mL in the CC:AC:AA groups, respectively; P=0.022). In contrast, there was no effect of carbamoyl-phosphate synthetase 1 genotype on the nitric oxide-independent tissue-type plasminogen activator response to bradykinin (P=0.943). These data indicate that a polymorphism in the gene encoding carbamoyl-phosphate synthetase 1 influences nitric oxide production as well as vascular smooth muscle reactivity."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.hyp.0000112424.06921.52"xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Harris S."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Brown N.J."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Weisberg A."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Vaughan D.E."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Gainer J.V."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Christman B.W."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Hall L.D."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Summar M.L."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Pretorius M."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/author | "Malave H."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/pages | "186-191"xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/title | "Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function."xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/14718356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14718356 |
| http://purl.uniprot.org/citations/14718356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14718356 |
| http://purl.uniprot.org/uniprot/P31327#attribution-A0905204E2BFD5B75DF108677C3357B0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14718356 |
| http://purl.uniprot.org/uniprot/P31327#attribution-CABDA6AAAF511ADBC8F5E38AAF1EEC36 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14718356 |
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| http://purl.uniprot.org/uniprot/#_B7ZAW0-mappedCitation-14718356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14718356 |
| http://purl.uniprot.org/uniprot/#_Q6PEK7-mappedCitation-14718356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14718356 |