| http://purl.uniprot.org/citations/14718571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14718571 | http://www.w3.org/2000/01/rdf-schema#comment | "Autosomal dominant polycystic kidney disease (ADPKD) is typified by the accumulation of fluid-filled cysts and abnormalities in renal epithelial cell function. The disease is principally caused by mutations in the gene encoding polycystin-1, a large basolateral plasma membrane protein expressed in kidney epithelial cells. Our studies reveal that, in normal kidney cells, polycystin-1 forms a complex with the adherens junction protein E-cadherin and its associated catenins, suggesting a role in cell adhesion or polarity. In primary cells from ADPKD patients, the polycystin-1/polycystin-2/E-cadherin/beta-catenin complex was disrupted and both polycystin-1 and E-cadherin were depleted from the plasma membrane as a result of the increased phosphorylation of polycystin-1. The loss of E-cadherin was compensated by the transcriptional upregulation of the normally mesenchymal N-cadherin. Increased cell surface N-cadherin in the disease cells in turn stabilized the continued plasma membrane localization of beta-catenin in the absence of E-cadherin. The results suggest that enhanced phosphorylation of polycystin-1 in ADPKD cells precipitates changes in its localization and its ability to form protein complexes that are critical for the stabilization of adherens junctions and the maintenance of a fully differentiated polarized renal epithelium."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e03-05-0296"xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Harris P.C."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Ness S.A."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Ward C.J."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Wandinger-Ness A."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Bacallao R."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/author | "Roitbak T."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/pages | "1334-1346"xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/title | "A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells."xsd:string |
| http://purl.uniprot.org/citations/14718571 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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