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http://purl.uniprot.org/citations/14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14719207http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To characterize the clinical pattern of psoriatic arthritis (PsA) sine psoriasis.

Methods

Fifty-seven patients (31 men, 26 women, mean age 46.32 +/-14.12 yrs) with undifferentiated spondyloarthropathy (SpA) were studied. Two subsets were defined: (1) 21 patients with familial psoriasis (12 men, 9 women, mean age 49.29 +/-14.17 yrs); (2) 36 patients without familial psoriasis (19 men, 17 women, mean age 44.58 +/-14.00 yrs). The prevalence of the following clinical variables was evaluated: low back pain, enthesopathy, dactylitis, distal interphalangeal (DIP) arthritis, spinal involvement, and discitis. In all patients the following HLA haplotypes were tested: B7, B13, B17, B18, B27, B38, Cw6, and DR7.

Results

Dactylitis and DIP arthritis were markedly present in the articular subset with familial psoriasis (p < 0.0001) that also showed a high frequency rate of HLA-Cw6 (p < 0.0001 vs controls and patients without familial psoriasis). HLA-B27 was markedly frequent in patients without familial psoriasis (p < 0.0001 vs controls and p = 0.019 vs patients with familial psoriasis). In addition, in patients with familial psoriasis the log-linear model showed that the presence of HLA-Cw6 was related to the presence of DIP arthritis as well as dactylitis (likelihood ratio chi-square change of 5.891 and p = 0.015).

Conclusion

A subset of patients with PsA "sine psoriasis" is identified by the occurrence of a SpA with dactylitis and/or DIP arthritis, presence of HLA-Cw6, and familial psoriasis in first or second-degree relatives."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Cosentini E."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Ayala F."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Atteno M."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"D'Arienzo A."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Manguso F."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Oriente A."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Oriente P."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Peluso R."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/author"Scarpa R."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/pages"2638-2640"xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/title"Clinical and genetic aspects of psoriatic arthritis "sine psoriasis"."xsd:string
http://purl.uniprot.org/citations/14719207http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/14719207http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14719207
http://purl.uniprot.org/citations/14719207http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14719207
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http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14719207
http://purl.uniprot.org/uniprot/#_A0A089N0V0-mappedCitation-14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14719207
http://purl.uniprot.org/uniprot/#_A0A0A7C850-mappedCitation-14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14719207
http://purl.uniprot.org/uniprot/#_A0A0A7C8P1-mappedCitation-14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14719207
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http://purl.uniprot.org/uniprot/#_A0A0A7C8P8-mappedCitation-14719207http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14719207