| http://purl.uniprot.org/citations/14726374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14726374 | http://www.w3.org/2000/01/rdf-schema#comment | "The stem cell leukemia (SCL) gene is essential for the development of hematopoietic stem cells in the embryo. Here, we used a conditional gene targeting approach to examine the function of SCL in adult hematopoietic stem cells (HSCs). Flow cytometry of bone marrow from SCL-deleted mice demonstrated a 4-fold increase in number of Lin(neg) c-kit(+) Sca-1(+) cells. Despite this increase in the number of phenotypic HSCs, competitive repopulation assays demonstrated a severe multilineage defect in repopulation capacity by SCL-deleted bone marrow cells. SCL-heterozygous cells also showed a mild repopulation defect, thus suggesting haploinsufficiency of SCL. The transplantation defect of SCL-deleted cells was observed within 4 weeks of transplantation, indicating a defect in a multipotent progenitor or short-term repopulating HSCs. Although the defect persisted in secondary transplants, it remained relatively stable, suggesting that SCL was not required for self-renewal of the HSCs. Generation of SCL-deleted cells within SCL-wild-type mice rescued the early repopulating defect. Together, our results suggest that SCL is required for the normal function of short-term repopulating HSCs."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2003-09-3202"xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Jane S.M."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Robb L."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Hall M.A."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Begley C.G."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Curtis D.J."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/author | "Van Stekelenburg L.J."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/pages | "3342-3348"xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/title | "SCL is required for normal function of short-term repopulating hematopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/14726374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14726374 |
| http://purl.uniprot.org/citations/14726374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14726374 |
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| http://purl.uniprot.org/uniprot/P22091 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/14726374 |
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