| http://purl.uniprot.org/citations/14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14726490 | http://www.w3.org/2000/01/rdf-schema#comment | "The importance of steroidogenic factor-1 (SF-1) gene dosage in endocrine function is evidenced by phenotypes associated with the heterozygous state in mice and humans. Here we examined mechanisms underlying SF-1 haploinsufficiency and found a striking reduction (12-fold) in SF-1 heterozygous (+/-) adrenocortical size at embryonic day (E) 12. Loss of one SF-1 allele led to a selective decrease in adrenal precursors within the adrenogonadal primordium at E10.0, without affecting the number of gonadal precursors, as marked by GATA-4. Beginning at E13.5, increased cell proliferation in SF-1 +/-adrenals allows these organs to approach but not attain a normal size. Remarkably, neural crest-derived adrenomedullary precursors migrated normally in SF-1 +/- and null embryos. However, later in development, medullary growth was compromised in both genotypes. Despite the small adrenal size in SF-1heterozygotes, an unexpected elevation in steroidogenic capacity per cell was observed in primary adult adrenocortical SF-1 +/-cells compared with wild-type cells. Elevated cellular steroid output is consistent with the up-regulation of some SF-1 target genes in SF-1 +/-adrenals and may partially be due to an observed increase in nerve growth factor-induced-B. Our findings underscore the need for full SF-1 gene dosage early in adrenal development, but not in the adult adrenal, where compensatory mechanisms restore near normal function."xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2003-0333"xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/author | "Ingraham H.A."xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/author | "Fowkes R.C."xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/author | "Bland M.L."xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/pages | "941-952"xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/title | "Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function."xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/14726490 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14726490 |
| http://purl.uniprot.org/citations/14726490 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWQ4-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY04-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A087WRU6-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A087WRA8-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_D3Z5U8-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A4K4Z6-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VJZ1-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_F7C5U2-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSV6-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_D3YTQ2-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_E9PXW9-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |
| http://purl.uniprot.org/uniprot/#_P45448-mappedCitation-14726490 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14726490 |