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http://purl.uniprot.org/citations/14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/14726620http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The recently observed increase in the incidence of type 1 diabetes mellitus (Type 1 DM) suggests a major role of environmental factors in the etiopathogenesis of the disease. The individual variation in cytochrome P(450)IID6 may influence the individual susceptibility to environmentally linked diseases. We aimed to evaluate the prevalence of cytochrome P(450)IID6 phenotypes in Hungarian children with Type 1 DM (n = 69) compared to healthy controls (n = 100).

Methods

Debrisoquine was administered orally and debrisoquine hydroxylation phenotype was determined as a metabolic ratio of urinary recovered debrisoquine and 4-hydroxydebrisoquine.

Results

Eight of the 100 healthy subjects (8%) and 15 of the 69 diabetic children (22%) (p < 0.05) had cytochrome P(450)IID6 poor metabolizer phenotype (metabolic ratio > or =12.6).

Conclusion

Cytochrome P(450)IID6's activity may play a role in the development of Type 1 DM."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.org/dc/terms/identifier"doi:10.1159/000076135"xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/author"Krikovszky D."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/author"Madacsy L."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/author"Barkai L."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/author"Santa A."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/name"Horm Res"xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/pages"176-179"xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/title"Altered distribution of the debrisoquine oxidative phenotypes in children with type 1 diabetes mellitus."xsd:string
http://purl.uniprot.org/citations/14726620http://purl.uniprot.org/core/volume"61"xsd:string
http://purl.uniprot.org/citations/14726620http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/14726620
http://purl.uniprot.org/citations/14726620http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/14726620
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http://purl.uniprot.org/uniprot/#_D5KN61-mappedCitation-14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14726620
http://purl.uniprot.org/uniprot/#_D5KN64-mappedCitation-14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14726620
http://purl.uniprot.org/uniprot/#_D5KNB5-mappedCitation-14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14726620
http://purl.uniprot.org/uniprot/#_D5KND2-mappedCitation-14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14726620
http://purl.uniprot.org/uniprot/#_C1ID52-mappedCitation-14726620http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/14726620
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