| http://purl.uniprot.org/citations/14729860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14729860 | http://www.w3.org/2000/01/rdf-schema#comment | "The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and mediates selective cholesteryl ester uptake, although much less efficiently than SR-BI. Apolipoprotein A-II (apoA-II), the second most abundant HDL protein, is considered to be proatherogenic, but the underlying mechanisms are unclear. We previously showed that apoA-II modulates SR-BI-dependent binding and selective uptake of cholesteryl ester from reconstituted HDL. To investigate the effect of apoA-II in naturally occurring HDL on these processes, we compared HDL without apoA-II (from apoA-II null mice) with HDLs containing differing amounts of apoA-II (from C57BL/6 mice and transgenic mice expressing a mouse apoA-II transgene). The level of apoA-II in HDL was inversely correlated with HDL binding and selective cholesteryl ester uptake by both scavenger receptors, particularly CD36. Interestingly, for HDL lacking apoA-II, the efficiency with which CD36 mediated selective uptake reached a level similar to that of SR-BI. These results demonstrate that apoA-II exerts a marked effect on HDL binding and selective lipid uptake by the class B scavenger receptors and establishes a potentially important relationship between apoA-II and CD36."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m300417-jlr200"xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "Cai L."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "Stromberg A.J."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "Castellani L.W."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "de Beer F.C."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "de Beer M.C."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/author | "van der Westhuyzen D.R."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/pages | "706-715"xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/title | "ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36."xsd:string |
| http://purl.uniprot.org/citations/14729860 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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