| http://purl.uniprot.org/citations/14729950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14729950 | http://www.w3.org/2000/01/rdf-schema#comment | "Oct-1 is a sequence-specific DNA binding transcription factor that is believed to regulate a large group of tissue-specific and ubiquitous genes. Both Oct-1 and the related but tissue-restricted Oct-2 protein bind to a DNA sequence termed the octamer motif (5'-ATGCAAAT-3') with equal affinity in vitro. To address the role of Oct-1 in vivo, an Oct-1-deficient mouse strain was generated by gene targeting. Oct-1-deficient embryos died during gestation, frequently appeared anemic, and suffered from a lack of Ter-119-positive erythroid precursor cells. This defect was cell intrinsic. Fibroblasts derived from these embryos displayed a dramatic decrease in Oct-1 DNA binding activity and a lack of octamer-dependent promoter activity in transient transfection assays. Interestingly, several endogenous genes thought to be regulated by Oct-1 showed no change in expression. When crossed to Oct-2(+/-) animals, transheterozygotes were recovered at a very low frequency. These findings suggest a critical role for Oct-1 during development and a stringent gene dosage effect with Oct-2 in mediating postnatal survival."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.3.1022-1032.2004"xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/author | "Sharp P.A."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/author | "Schmidt T."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/author | "Tantin D."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/author | "Wang V.E."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/pages | "1022-1032"xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/title | "Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/14729950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14729950 |
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