| http://purl.uniprot.org/citations/14730349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14730349 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14730349 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. The MO25 alpha crystal structure reveals a helical repeat fold, distantly related to the Armadillo proteins. A complex with the STRAD alpha peptide reveals a hydrophobic pocket that is involved in a unique and specific interaction with the Trp-Glu-Phe motif, further supported by mutagenesis studies. The data represent a first step toward structural analysis of the LKB1-STRAD-MO25 complex, and suggests that MO25 alpha is a scaffold protein to which other regions of STRAD-LKB1, cellular LKB1 substrates or regulatory components could bind."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb716"xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb716"xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Alessi D.R."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Alessi D.R."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Milburn C.C."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Milburn C.C."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Boudeau J."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Boudeau J."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Deak M."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "Deak M."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "van Aalten D.M."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/author | "van Aalten D.M."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/pages | "193-200"xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/pages | "193-200"xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/title | "Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/title | "Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor."xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/14730349 | http://purl.uniprot.org/core/volume | "11"xsd:string |