| http://purl.uniprot.org/citations/14732705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14732705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14732705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/14732705 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulated intramembrane proteolysis (RIP) is an emerging paradigm in signal transduction. RIP is mediated by intramembrane-cleaving proteases (I-CliPs), which liberate biologically active nuclear or secreted domains from their membrane-tethered precursor proteins. The yeast Pcp1p/Rbd1p protein is a Rhomboid-like I-CliP that regulates mitochondrial membrane remodeling and fusion through cleavage of Mgm1p, a regulator of these essential activities. Although this ancient function is conserved in PARL (Presenilins-associated Rhomboid-like protein), the mammalian ortholog of Pcp1p/Rbd1p, the two proteins show a strong divergence at their N termini. However, the N terminus of PARL is significantly conserved among vertebrates, particularly among mammals, suggesting that this domain evolved a distinct but still unknown function. Here, we show that the cytosolic N-terminal domain of PARL is cleaved at positions 52-53 (alpha-site) and 77-78 (beta-site). Whereas alpha-cleavage is constitutive and removes the mitochondrial targeting sequence, beta-cleavage appears to be developmentally controlled and dependent on PARL I-CliP activity supplied in trans. The beta-cleavage of PARL liberates Pbeta, a nuclear targeted peptide whose sequence is conserved only in mammals. Thus, in addition to its evolutionarily conserved function in regulating mitochondrial dynamics, PARL might mediate a mammalian-specific, developmentally regulated mitochondria-to-nuclei signaling through regulated proteolysis of its N terminus and release of the Pbeta peptide."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313756200"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313756200"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Koonin E.V."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Koonin E.V."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Pellegrini L."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Pellegrini L."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Passer B.J."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Passer B.J."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Sik A."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/author | "Sik A."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/pages | "15323-15329"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/pages | "15323-15329"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/title | "Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/title | "Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide."xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14732705 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14732705 |