| http://purl.uniprot.org/citations/14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14733929 | http://www.w3.org/2000/01/rdf-schema#comment | "The production of eotaxin, which is a critical mediator for airway inflammation, is inhibited by IFN-gamma. Here, we investigated the precise mechanisms underlying IFN-gamma-dependent inhibition of eotaxin production using mouse embryonic fibroblasts (MEF). MEF produced high levels of eotaxin in STAT6-dependent manner when they were cultured with both IL-4 and TNF-alpha. However, the eotaxin production by MEF was strongly inhibited by addition of IFN-gamma. Western-blotting analysis demonstrated that IFN-gamma downmodulated STAT6 phosphorylation induced by IL-4 and TNF-alpha. Moreover, IFN-gamma did not exhibit its inhibitory effect on both STAT6-phosphorylation and eotaxin production in MEF obtained from deficient mice in STAT1, a key molecule of IFN-gamma signaling. We also demonstrated that SOCS-1, a potent inhibitory molecule of IL-4 signaling, was induced by IFN-gamma in STAT1-dependent manner. This indicated that SOCS-1 might be involved in IFN-gamma-mediated STAT1-dependent inhibition of eotaxin production. In SOCS-1(-/-) MEF, IFN-gamma inhibited neither STAT6 phosphorylation nor eotaxin production induced by IL-4 and TNF-alpha. Conversely, retroviral transduction of SOCS-1 into MEF inhibited STAT6 phosphorylation and eotaxin production induced by IL-4 and TNF-alpha, in the absence of IFN-gamma. Thus, we demonstrated that IFN-gamma-induced inhibition of STAT6 phosphorylation and eotaxin production were mediated by SOCS-1 induced in STAT1-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2003.12.124"xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Nishimura T."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Takeshima H."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Saito R."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Tsuji T."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Matsuzaki J."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Koda T."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Jinushi T."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/author | "Nishimura S.i."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/pages | "468-475"xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/title | "IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha."xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/14733929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14733929 |
| http://purl.uniprot.org/citations/14733929 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14733929 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |
| http://purl.uniprot.org/uniprot/#_Q0X0E6-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-14733929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14733929 |