| http://purl.uniprot.org/citations/14734535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734535 | http://www.w3.org/2000/01/rdf-schema#comment | "Dishevelled (DVL) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3beta (GSK-3beta). In the canonical WNT pathway, the negative regulator Axin forms a complex with beta-catenin and GSK-3beta, resulting in beta-catenin degradation. Inhibition of GSK-3beta by DVL increases beta-catenin stability and TCF transcriptional activation. Here, we show that Axin associates with microtubules and unexpectedly stabilizes microtubules through DVL. In turn, DVL stabilizes microtubules by inhibiting GSK-3beta through a transcription- and beta-catenin-independent pathway. More importantly, axonal microtubules are stabilized after DVL localizes to axons. Increased microtubule stability is correlated with a decrease in GSK-3beta-mediated phosphorylation of MAP-1B. We propose a model in which Axin, through DVL, stabilizes microtubules by inhibiting a pool of GSK-3beta, resulting in local changes in the phosphorylation of cellular targets. Our data indicate a bifurcation in the so-called canonical WNT-signaling pathway to regulate microtubule stability."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200309096"xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/author | "Dale T.C."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/author | "Ciani L."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/author | "Salinas P.C."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/author | "Krylova O."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/author | "Smalley M.J."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/pages | "243-253"xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/title | "A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules."xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://purl.uniprot.org/core/volume | "164"xsd:string |
| http://purl.uniprot.org/citations/14734535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14734535 |
| http://purl.uniprot.org/citations/14734535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14734535 |
| http://purl.uniprot.org/uniprot/O35625#attribution-CC438256EDBE7492E42A4AC7832A63AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14734535 |
| http://purl.uniprot.org/uniprot/O35625#attribution-D36CE2A764E4D3488F7091EE021A4864 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14734535 |
| http://purl.uniprot.org/uniprot/P51141#attribution-CC438256EDBE7492E42A4AC7832A63AA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14734535 |
| http://purl.uniprot.org/uniprot/P51141#attribution-D36CE2A764E4D3488F7091EE021A4864 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/14734535 |
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| http://purl.uniprot.org/uniprot/#_O35625-mappedCitation-14734535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/14734535 |