| http://purl.uniprot.org/citations/14734547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734547 | http://www.w3.org/2000/01/rdf-schema#comment | "The XPF/ERCC1 heterodimer is a DNA structure-specific endonuclease that participates in nucleotide excision repair and homology-dependent recombination reactions, including DNA single strand annealing and gene targeting. Here we show that XPF/ERCC1 is stably associated with hRad52, a recombinational repair protein, in human cell-free extracts and that these factors interact directly via the N-terminal domain of hRad52 and the XPF protein. Complex formation between hRad52 and XPF/ERCC1 concomitantly stimulates the DNA structure-specific endonuclease activity of XPF/ERCC1 and attenuates the DNA strand annealing activity of hRad52. Our results reveal a novel role for hRad52 as a subunit of a DNA structure-specific endonuclease and are congruent with evidence implicating both hRad52 and XPF/ERCC1 in a number of homologous recombination reactions. We propose that the ternary complex of hRad52 and XPF/ERCC1 is the active species that processes recombination intermediates generated during the repair of DNA double strand breaks and in homology-dependent gene targeting events."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m313779200"xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/author | "Tomkinson A.E."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/author | "Sung P."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/author | "Post S.M."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/author | "Bessho T."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/author | "Motycka T.A."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/pages | "13634-13639"xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/title | "Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52."xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/14734547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14734547 |
| http://purl.uniprot.org/citations/14734547 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/14734547 |
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