| http://purl.uniprot.org/citations/14734769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/14734769 | http://www.w3.org/2000/01/rdf-schema#comment | "Several lines of in vitro evidence suggest the potential role of IFN-gamma in angiogenesis and collagen deposition, two crucial steps in the wound healing process. In this report, we examined the role of IFN-gamma in the skin wound healing process utilizing WT and IFN-gamma KO mice. In WT mice, excisional wounding induced IFN-gamma mRNA and protein expression by infiltrating macrophages and T cells, with a concomitant enhancement of IL-12 and IL-18 gene expression. Compared with WT mice, IFN-gamma KO mice exhibited an accelerated wound healing as evidenced by rapid wound closure and granulation tissue formation. Moreover, IFN-gamma KO mice exhibited enhanced angiogenesis with augmented vascular endothelial growth factor mRNA expression in wound sites, compared with WT mice, despite a reduction in the infiltrating neutrophils, macrophages, and T cells. IFN-gamma KO mice also exhibited accelerated collagen deposition with enhanced production of TGF-beta1 protein in wound sites, compared with WT mice. Furthermore, the absence of IFN-gamma augmented the TGF-beta1-mediated signaling pathway, as evidenced by increases in the levels of total and phosphorylated Smad2 and a reciprocal decrease in the levels of Smad7. These results demonstrate that there is crosstalk between the IFN-gamma/Stat1 and TGF-beta1/Smad signaling pathways in the wound healing process."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.172.3.1848"xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/author | "Ishida Y."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/author | "Mukaida N."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/author | "Takayasu T."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/pages | "1848-1855"xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/title | "The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process."xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://purl.uniprot.org/core/volume | "172"xsd:string |
| http://purl.uniprot.org/citations/14734769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/14734769 |
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